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One Woman's Triumph
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A Ray of Hope:
One Woman's Triumph over Cancer


Dr. George Carrum
Hematologist, Center for
Cell and Gene Therapy
In November 2004, Monica Saynez was diagnosed with acute myelogenous leukemia (AML). At the time of her diagnosis, she was a wife and mother of a 6-month-old baby girl. Facing the grim reality of cancer, Monica traveled thousands of miles to The Methodist Hospital to receive world-class cancer care from some of the nation's top physicians, including Hector Preti, M.D., oncologist. "I started chemotherapy at Methodist, but it was decided that I needed a transplant because the chemo just wasn't enough," Monica explains.

At that point, Monica was transferred to The Methodist Hospital's Center for Cell and Gene Therapy, where she met George Carrum, M.D., hematologist. "The purpose of cell and gene therapy is to provide transplants for patients with different diseases, such as leukemia, lymphoma and bone marrow disorders," Dr. Carrum says. Before a transplant could be performed, Monica and Dr. Carrum needed to find the last piece of the puzzle: a donor.

Finding a Donor
When searching for a donor, doctors typically start with a patient’s siblings because there is a 25% chance that a brother or sister will be a match. However, Monica does not have biological siblings, so the search expanded to a national registry of donors. "We were able to find a female donor who provided a close match for Monica," Dr. Carrum says. After receiving the news, Monica felt blessed as she began to prepare for the transplant.


Monica Saynez with daughter Paola.
The Transplant
Physicians in the Cell and Gene Therapy Center typically perform two types of transplants for patients with benign or malignant diseases: allogeneic or autologous. Monica received the former, in which stem cells are collected from a donor and injected into the patient to help produce new, healthy stem cells within the
bone marrow.

There are two ways to collect stem cells from donors – either from the bone marrow directly in the operating room or through a procedure in which the donor is given shots of Neupogen under the skin to stimulate white cells, which then release bone marrow cells. "After five days of injections, the donor is put on a machine that collects the stem cells. They can be used fresh through an IV (in Monica's case) or stored away," says Dr. Carrum.

Every Day Is a New Day
Monica's transplant was successful and she is now in remission. "Thanks to my donor and my physicians at The Methodist Hospital, I'm here," she says. "I'm living a normal life, and I'm so happy to be with my 3-year-old daughter. Every survivor feels fortunate to have a second chance at life." Monica was able to meet her donor a year after the transplant and now considers her a friend and sister. "This beautiful lady not only became my donor but sent me cards and letters of encouragement during a difficult time." To show her gratitude for the care and support she received, Monica is volunteering at The Methodist Hospital two days a week. "If I can give back just a little, I'll be happy," she says.

Getting the Facts
Acute Myelogenous Leukemia (AML)
  • Nearly 12,000 new cases are diagnosed in the United States each year.
  • This form of cancer typically occurs in people age 65 and older, but can affect all ages.
  • The disease affects the bone marrow and blood.
  • With this type of cancer, white blood cells, red blood cells and platelets are often reduced (needed to fight infection, carry oxygen to the body and control bleeding).
  • Treatment options may include chemotherapy or bone marrow transplant.

* Source: The Leukemia and Lymphoma Society.

The Methodist Hospital is involved in novel research, such as immunotherapies and vaccine therapies, to help discover new treatments for cancer. You can make a difference in a cancer patient’s life by becoming a stem cell donor. New donors are needed daily, and the donation process can be completed right at The Methodist Hospital. For more information, please call 888-285-5314 or visit www.methodisthealth.com/cancer.

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